Factors associated with COVID-19-related death using OpenSAFELY

被引：4361

作者：

Williamson, Elizabeth J. ^{[1
]}

Walker, Alex J. ^{[2
]}

Bhaskaran, Krishnan ^{[1
]}

Bacon, Seb ^{[2
]}

Bates, Chris ^{[3
]}

Morton, Caroline E. ^{[2
]}

Curtis, Helen J. ^{[2
]}

Mehrkar, Amir ^{[2
]}

Evans, David ^{[2
]}

Inglesby, Peter ^{[2
]}

Cockburn, Jonathan ^{[3
]}

McDonald, Helen, I ^{[1
,4
]}

MacKenna, Brian ^{[2
]}

Tomlinson, Laurie ^{[1
]}

Douglas, Ian J. ^{[1
]}

Rentsch, Christopher T. ^{[1
]}

Mathur, Rohini ^{[1
]}

Wong, Angel Y. S. ^{[1
]}

Grieve, Richard ^{[1
]}

Harrison, David ^{[5
]}

Forbes, Harriet ^{[1
]}

Schultze, Anna ^{[1
]}

Croker, Richard ^{[2
]}

Parry, John ^{[3
]}

Hester, Frank ^{[3
]}

Harper, Sam ^{[3
]}

Perera, Rafael ^{[2
]}

Evans, Stephen J. W. ^{[1
]}

Smeeth, Liam ^{[1
,4
]}

Ben Goldacre ^{[2
]}

机构：

[1] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hearth, London, England

[2] Univ Oxford, Nuffield Dept Primary Care Hearth Sci, DataLab, Oxford, England

[3] TPP, Horsforth, England

[4] NIHR Hearth Protect Res Unit Immunisat, London, England

[5] Intens Care Natl Audit & Res Ctr ICNARC, London, England

来源：

NATURE | 2020年 / 584卷 / 7821期

基金：

英国惠康基金;

关键词：

PRIMARY-CARE; HEALTH; RATES;

D O I：

10.1038/s41586-020-2521-4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Coronavirus disease 2019 (COVID-19) has rapidly affected mortality worldwide(1). There is unprecedented urgency to understand who is most at risk of severe outcomes, and this requires new approaches for the timely analysis of large datasets. Working on behalf of NHS England, we created OpenSAFELY-a secure health analytics platform that covers 40% of all patients in England and holds patient data within the existing data centre of a major vendor of primary care electronic health records. Here we used OpenSAFELY to examine factors associated with COVID-19-related death. Primary care records of 17,278,392 adults were pseudonymously linked to 10,926 COVID-19-related deaths. COVID-19-related death was associated with: being male (hazard ratio (HR) 1.59 (95% confidence interval 1.53-1.65)); greater age and deprivation (both with a strong gradient); diabetes; severe asthma; and various other medical conditions. Compared with people of white ethnicity, Black and South Asian people were at higher risk, even after adjustment for other factors (HR 1.48 (1.29-1.69) and 1.45 (1.32-1.58), respectively). We have quantified a range of clinical factors associated with COVID-19-related death in one of the largest cohort studies on this topic so far. More patient records are rapidly being added to OpenSAFELY, we will update and extend our results regularly. OpenSAFELY, a new health analytics platform that includes data from over 17 million adult NHS patients in England, is used to examine factors associated with COVID-19-related death.

引用

页码：430 / +

页数：14

共 54 条

[1]

Adams S., 2019, ANN ONCOL, DOI DOI 10.1093/annonc/mdy518

[2]

[Anonymous], UK IMM SCHED GREEN B

[3]

[Anonymous], 2020, INTERNET RES, DOI [DOI 10.2196/17003, DOI 10.2196/19556]

[4]

Boddington NL., 2020, COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis, DOI [10.1101/2020.05.18.20086157, DOI 10.1101/2020.05.18.20086157]

[5]

Campbell A., 2020, The West Australian

[6]

Carpenter J., 2012, Multiple imputation and its application

[7]

Development and validation of an electronic frailty index using routine primary care electronic health record data [J].

Clegg, Andrew ;

Bates, Chris ;

Young, John ;

Ryan, Ronan ;

Nichols, Linda ;

Teale, Elizabeth Ann ;

Mohammed, Mohammed A. ;

Parry, John ;

Marshall, Tom .

AGE AND AGEING, 2016, 45 (03) :353-360

[8]

Clinical determinants for fatality of 44,672 patients with COVID-19 [J].

Deng, Guangtong ;

Yin, Mingzhu ;

Chen, Xiang ;

Zeng, Furong .

CRITICAL CARE, 2020, 24 (01)

[9]

Department of Health and Social Care, 2020, COR COVID 19 NOT ORG

[10]

Department of Social Care and Public Health England, 2020, NUMB COR COVID 19 CA

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