KLF6, a candidate tumor suppressor gene mutated in prostate cancer

被引：380

作者：

Narla, G

Heath, KE

Reeves, HL

Li, D

Giono, LE

Kimmelman, AC

Glucksman, MJ

Narla, J

Eng, FJ

Chan, AM

Ferrari, AC

Martignetti, JA

Friedman, SL

机构：

[1] CUNY Mt Sinai Sch Med, Dept Med, Div Liver Dis, New York, NY 10029 USA

[2] CUNY Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA

[3] CUNY Mt Sinai Sch Med, Derald H Ruttenberg Canc Ctr, New York, NY 10029 USA

[4] CUNY Mt Sinai Sch Med, Dept Neurobiol, New York, NY 10029 USA

[5] CUNY Mt Sinai Sch Med, Dept Med, Div Med Oncol, New York, NY 10029 USA

[6] CUNY Mt Sinai Sch Med, Dept Pediat, New York, NY 10029 USA

[7] Reg Med Ctr, San Jose, CA 95116 USA

来源：

SCIENCE | 2001年 / 294卷 / 5551期

关键词：

D O I：

10.1126/science.1066326

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor of unknown function. Here, we show that the KLF6 gene is mutated in a subset of human prostate cancer. Loss-of-heterozygosity analysis revealed that one KLF6 allele is deleted in 77% (17 of 22) of primary prostate tumors. Sequence analysis of the retained KLF6 allele revealed mutations in 71% of these tumors. Functional studies confirm that whereas wild-type KLF6 up-regulates p21 (WAF1/CIP1) in a p53-independent manner and significantly reduces cell proliferation, tumor-derived KLF6 mutants do not. Our data suggest that KLF6 is a tumor suppressor gene involved in human prostate cancer.

引用

页码：2563 / 2566

页数：4

共 15 条

[1] Kruppel-like factors: Three fingers in many pies [J].