Squalene-hopene cyclase: catalytic mechanism and substrate recognition

被引：166

作者：

Hoshino, T ^{[1
]}

Sato, T ^{[1
]}

机构：

[1] Niigata Univ, Fac Agr, Dept Appl Biol Chem, Niigata 9502181, Japan

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 04期

关键词：

D O I：

10.1039/b108995c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rapid progress on the catalytic mechanism and substrate recognition by squalene-hopene cyclase, which has occurred only in the last several years, is reported. A series of site-directed mutation experiments and some squalene analogues have provided deep insight into the polycyclization mechanism and catalytic sites in conjunction with the information from X-ray crystal data.

引用

页码：291 / 301

页数：11

共 71 条

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