FloDots: luminescent nanoparticles

被引：130

作者：

Yao, Gang

Wang, Lin

Wu, Yanrong

Smith, Josh

Xu, Jinsheng

Zhao, Wenjun

Lee, Eunjung

Tan, Weihong ^{[1
]}

机构：

[1] Univ Florida, Ctr Res Bionano Interface, Dept Chem, Gainesville, FL 32611 USA

[2] Univ Florida, Shands Canc Ctr, Gainesville, FL 32611 USA

[3] Life Sci Inc, St Petersburg, FL 33710 USA

[4] Hengyang Normal Univ, Dept Chem, Hengyang 421008, Hunan, Peoples R China

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2006年 / 385卷 / 03期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

dye-doped silica nanoparticles; nanotechnology; bioanalysis;

D O I：

10.1007/s00216-006-0452-z

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Luminescent dye-doped silica nanoparticles (FloDots) have been developed for ultrasensitive bioanalysis and diagnosis in the past several years. Those novel nanoparticles are highly luminescent and extremely photostable. In this paper, we review the preparation, characterization, bioconjugation and bioapplication of FloDots. All the results clearly demonstrated that FloDots have many advantages over currently used luminescent probes, such as traditional fluorophores and quantum dots.

引用

收藏

页码：518 / 524

页数：7

相关论文

共 29 条

[1] A method for quantifying differential expansion within hydrating hydrophilic matrixes by tracking embedded fluorescent microspheres [J].

Adler, J ;

Jayan, A ;

Melia, CD .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1999, 88 (03) :371-377

[2] Bioconjugated luminescent nanoparticles for biological applications [J].

Bagwe, RP ;

Zhao, XJ ;

Tan, WH .

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, 2003, 24 (3-4) :453-464

[3] Optimization of dye-doped silica nanoparticles prepared using a reverse microemulsion method [J].

Bagwe, RP ;

Yang, CY ;

Hilliard, LR ;

Tan, WH .

LANGMUIR, 2004, 20 (19) :8336-8342

[4] A NEW IMMUNOREAGENT FOR CELL LABELING - CD3 MONOCLONAL-ANTIBODY COVALENTLY COUPLED TO FLUORESCENT POLYMETHACRYLIC NANOPARTICLES [J].

BOUREL, D ;

ROLLAND, A ;

LEVERGE, R ;

GENETET, B .

JOURNAL OF IMMUNOLOGICAL METHODS, 1988, 106 (02) :161-167

[5] Quantum dot bioconjugates for ultrasensitive nonisotopic detection [J].

Chan, WCW ;

Nie, SM .

SCIENCE, 1998, 281 (5385) :2016-2018

[6] Designing a novel molecular beacon for surface-immobilized DNA hybridization studies [J].

Fang, XH ;

Liu, XJ ;

Schuster, S ;

Tan, WH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (12) :2921-2922

[7] Colloidal Au-enhanced surface plasmon resonance for ultrasensitive detection of DNA hybridization [J].

He, L ;

Musick, MD ;

Nicewarner, SR ;

Salinas, FG ;

Benkovic, SJ ;

Natan, MJ ;

Keating, CD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (38) :9071-9077

[8] Immobilization of oligonucleotides onto silica nanoparticles for DNA hybridization studies [J].

Hilliard, LR ;

Zhao, XJ ;

Tan, WH .

ANALYTICA CHIMICA ACTA, 2002, 470 (01) :51-56

[9] Spectroscopy of fluorescein (FITC) dyed colloidal silica spheres [J].

Imhof, A ;

Megens, M ;

Engelberts, JJ ;

de Lang, DTN ;

Sprik, R ;

Vos, WL .

JOURNAL OF PHYSICAL CHEMISTRY B, 1999, 103 (09) :1408-1415

[10] A review of molecular recognition technologies for detection of biological threat agents [J].

Iqbal, SS ;

Mayo, MW ;

Bruno, JG ;

Bronk, BV ;

Batt, CA ;

Chambers, JP .

BIOSENSORS & BIOELECTRONICS, 2000, 15 (11-12) :549-578