IL-18 gene polymorphisms affect IL-18 production capability by monocytes

被引：107

作者：

Arimitsu, J ^{[1
]}

Hirano, T ^{[1
]}

Higa, S ^{[1
]}

Kawal, M ^{[1
]}

Naka, T ^{[1
]}

Ogata, A ^{[1
]}

Shima, Y ^{[1
]}

Fujimoto, M ^{[1
]}

Yamadori, T ^{[1
]}

Hagiwara, K ^{[1
]}

Ohgawara, T ^{[1
]}

Kuwabara, Y ^{[1
]}

Kawase, I ^{[1
]}

Tanaka, T ^{[1
]}

机构：

[1] Osaka Univ, Sch Med, Dept Resp Med Allergy & Rheumat Dis, Osaka 5650871, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 342卷 / 04期

关键词：

IL-18; SNP; asthma; monocyte;

D O I：

10.1016/j.bbrc.2006.02.096

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We previously demonstrated a significant association between IL-18 gene polymorphism 105 A/C and asthma. In this study, we investigated the relationship of IL-18 gene polymorphism to IL-18 production capability by monocytes. The frequency of gene polymorphisms including IL-18-105 A/C and IL-18--137G/C was determined by PCR analyses. The IL-18 production by monocytes stimulated without or with LPS or A23187 + PMA for 1 day was measured by ELISA. The produced IL-18 spontaneously or in response to A23187 + PMA by monocytes was significantly higher for Volunteers with 105 A/A genotype than with 105 A/C genotype. Similarly, the production capability of IL-18 by monocytes from Volunteers with -137 G/G genotype was significantly higher than that with -137 G/C genotype and significant linkage disequilibrium was observed between 105 A/C and -137 G/C polymorphism. Thus, the genetic capacity to produce more IL-18 in response to stimuli may affect the onset of asthma. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1413 / 1416

页数：4

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