The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness

被引：237

作者：

Saint Andre, AV

Blackwell, NM

Hall, LR

Hoerauf, A

Brattig, NW

Volkmann, L

Taylor, MJ

Ford, L

Hise, AG

Lass, JH

Diaconu, E

Pearlman, E ^{[1
]}

机构：

[1] Univ Hosp Cleveland, Div Geog Med, Cleveland, OH 44106 USA

[2] Univ Hosp Cleveland, Dept Ophthalmol, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Cleveland, OH 44106 USA

[4] Bernhard Nocht Inst Trop Med, D-20359 Hamburg, Germany

[5] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England

来源：

SCIENCE | 2002年 / 295卷 / 5561期

关键词：

D O I：

10.1126/science.1068732

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Parasitic filarial nematodes infect more than 200 million individuals worldwide, causing debilitating inflammatory diseases such as river blindness and lymphatic filariasis. Using a murine model for river blindness in which soluble extracts of filarial nematodes were injected into the corneal stroma, we demonstrated that the predominant inflammatory response in the cornea was due to species of endosymbiotic Wolbachia bacteria. In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells.

引用

页码：1892 / 1895

页数：4

共 22 条

[1] Lipopolysaccharide-like molecules derived from Wolbachia endobacteria of the filaria Onchocerca volvulus are candidate mediators in the sequence of inflammatory and antiinflammatory responses of human monocytes [J].