The ABC transporter structure and mechanism: perspectives on recent research

被引：460

作者：

Jones, PM ^{[1
]}

George, AM ^{[1
]}

机构：

[1] Univ Technol Sydney, Dept Cell & Mol Biol, Broadway, NSW 2007, Australia

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2004年 / 61卷 / 06期

关键词：

ABC transporter; ABC-ATPase; membrane transport; nucleotide-binding domain; ATP hydrolysis; mechanism; P-glycoprotein;

D O I：

10.1007/s00018-003-3336-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ATP-binding cassette (ABC) transporters are multidomain integral membrane proteins that utilise the energy of ATP hydrolysis to translocate solutes across cellular membranes in all phyla. ABC transporters form one of the largest of all protein families and are central to many important biomedical phenomena, including resistance of cancers and pathogenic microbes to drugs. Elucidation of the structure and mechanism of ABC transporters is essential to the rational design of agents to control their function. While a wealth of high-resolution structures of ABC proteins have been produced in recent years, many fundamental questions regarding the protein's mechanism remain unanswered. In this review, we examine the recent structural data concerning ABC transporters and related proteins in the light of other experimental and theoretical data, and discuss these data in relation to current ideas concerning the transporters' molecular mechanism.

引用

页码：682 / 699

页数：18

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