Tension precedes commitment - Even for a stem cell

被引：42

作者：

Settleman, J

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

来源：

MOLECULAR CELL | 2004年 / 14卷 / 02期

关键词：

D O I：

10.1016/S1097-2765(04)00207-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The differentiation potential of stem cells is influenced by cell density. An article in the April issue of Developmental Cell (McBeath et al., 2004) demonstrates that lineage commitment by mesenchymal stem cells is regulated by shape-induced changes in Rho GTPase activity and cytoskeletal tension.

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收藏

页码：148 / 150

页数：3

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