Chemical modifications and structure activity studies of ziracin and related everninomicin antibiotics

被引：18

作者：

Ganguly, AK ^{[1
]}

McCormick, JL ^{[1
]}

Saksena, AK ^{[1
]}

Das, PR ^{[1
]}

Chan, TM ^{[1
]}

机构：

[1] Schering Plough Res Inst, Chem Res, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(99)00163-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical modifications of everninomicin antibiotics, particularly ziracin (1), were carried out to study the SARs as well as the chemical properties of this class of compounds. Use of allyl ether group for protection and selective deprotection of phenolic groups provided access to a variety of novel analogs of the title compounds, some of which exhibited the same high in vitro potency as the parent compounds. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1209 / 1214

页数：6

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