RNA Polymerase Backtracking in Gene Regulation and Genome Instability

被引：208

作者：

Nudler, Evgeny ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Biochem & Mol Pharmacol, New York, NY 10016 USA

来源：

CELL | 2012年 / 149卷 / 07期

关键词：

INTRINSIC TRANSCRIPTION TERMINATION; II ELONGATION COMPLEX; CLEAVAGE FACTORS GREA; ESCHERICHIA-COLI; STRUCTURAL BASIS; TRIGGER LOOP; DNA HYBRID; NASCENT TRANSCRIPT; SIGMA(70) SUBUNIT; ALPHA-AMANITIN;

D O I：

10.1016/j.cell.2012.06.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA polymerase is a ratchet machine that oscillates between productive and backtracked states at numerous DNA positions. Since its first description 15 years ago, backtracking - the reversible sliding of RNA polymerase along DNA and RNA - has been implicated in many critical processes in bacteria and eukaryotes, including the control of transcription elongation, pausing, termination, fidelity, and genome instability. © 2012 Elsevier Inc.

引用

页码：1438 / 1445

页数：8

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