Growth phase-dependent regulation of Vsr endonuclease may contribute to 5-methylcytosine mutational hot spots in Escherichia coli

被引：17

作者：

Macintyre, G ^{[1
]}

Pitsikas, P ^{[1
]}

Cupples, CG ^{[1
]}

机构：

[1] Concordia Univ, Dept Biol, Montreal, PQ H3G 1M8, Canada

来源：

JOURNAL OF BACTERIOLOGY | 1999年 / 181卷 / 14期

关键词：

D O I：

10.1128/JB.181.14.4435-4436.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Using rabbit polyclonal antibodies, we have shown that the Dcm cytosine methylase of Escherichia coli is maintained at a constant level during cell growth, while Vsr endonuclease levels are growth phase dependent. Decreased production of Vsr relative to Dcm during the log phase may contribute substantially to the mutability of 5-methylcytosine.

引用

页码：4435 / 4436

页数：2

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