Chromatin-tethered MAPKs

被引：67

作者：

Klein, Aileen M. ^{[1
]}

Zaganjor, Elma ^{[1
]}

Cobb, Melanie H. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2013年 / 25卷 / 02期

关键词：

ACTIVATED PROTEIN-KINASES; C-FOS PROMOTER; TRANSCRIPTION FACTOR; GENE-EXPRESSION; TARGET GENES; BETA-CELLS; PHOSPHORYLATION; COMPLEX; RECEPTOR; ESTROGEN;

D O I：

10.1016/j.ceb.2013.01.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Mitogen-activated protein kinases (MAPKs) are a family of protein kinases that are essential nodes in many cellular regulatory circuits including those that take place on DNA. Most members of the four MAPK subgroups that exist in canonical three kinase cascades - extracellular signal-regulated kinases 1 and 2 (ERK1/2), ERK5, c-Jun N-terminal kinases (JNK1-3), and p38 (alpha, beta, gamma, and delta) families - have been shown to perform regulatory functions on chromatin. This review offers a brief update on the variety of processes that involve MAPKs and available mechanisms garnered in the last two years.

引用

页码：272 / 277

页数：6

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