The biosynthesis of the Streptomyces antibiotic bicyclomycin

被引：9

作者：

Bradley, EL

Herbert, RB

Lawrie, KWM

Khan, JA

Moody, CM

Young, DW

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ESSEX,ENGLAND

[2] UNIV LEEDS,SCH CHEM,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

[3] UNIV SUSSEX,SCH CHEM & MOL SCI,BRIGHTON BN1 9QJ,E SUSSEX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 38期

关键词：

D O I：

10.1016/0040-4039(96)01521-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bicyclomycin 5 is biosynthesized in Streptomyces sapporonensis from L-leucine 2 and L-isoleucine 1 by way of the naturally occurring diketopiperazine 3 and dihydrobicyclomycin 4. The mode of incorporation of (2S,4R)-[5,5,5-H-2(3)]leucine into 5 (and 4) shows that the entry of the hydroxy group at C-2' occurs with unusual inversion of configuration. The results of inhibition studies permit a useful working hypothesis to be advanced for bicyclomycin biosynthesis. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：6935 / 6938

页数：4

共 13 条

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