A microfluidic device for conducting gas-liquid-solid hydrogenation reactions

被引：493

作者：

Kobayashi, J

Mori, Y

Okamoto, K

Akiyama, R

Ueno, M

Kitamori, T

Kobayashi, S

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Grad Sch Engn, Dept Appl Chem, Bunkyo Ku, Tokyo 1138656, Japan

来源：

SCIENCE | 2004年 / 304卷 / 5675期

关键词：

D O I：

10.1126/science.1096956

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have developed an efficient system for triphase reactions using a micro-channel reactor. Using this system, we conducted hydrogenation reactions that proceeded smoothly to afford the desired products quantitatively within 2 minutes for a variety of substrates. The system could also be applied to deprotection reactions. We could achieve an effective interaction between hydrogen, substrates, and a palladium catalyst using extremely large interfacial areas and the short path required for molecular diffusion in the very narrow channel space. This concept could be extended to other multiphase reactions that use gas-phase reagents such as oxygen and carbon dioxide.

引用

页码：1305 / 1308

页数：4

共 37 条

[1] The polymer incarcerated method for the preparation of highly active heterogeneous palladium catalysts [J].

Akiyama, R ;

Kobayashi, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (12) :3412-3413

[2]

Akiyama R, 2002, ANGEW CHEM INT EDIT, V41, P2602, DOI 10.1002/1521-3773(20020715)41:14<2602::AID-ANIE2602>3.0.CO

[3]

2-3

[4]

Akiyama R, 2001, ANGEW CHEM INT EDIT, V40, P3469, DOI 10.1002/1521-3773(20010917)40:18<3469::AID-ANIE3469>3.0.CO

[5]

2-T

[6] HYDROGENATION AND HYDROGENOLYSIS [J].

ARNOLD, MR .

INDUSTRIAL AND ENGINEERING CHEMISTRY, 1956, 48 (09) :1629-1642

[7] Hydrocarbon hydrogenation and dehydrogenation reactions in microfabricated catalytic reactors [J].

Besser, RS ;

Ouyang, X ;

Surangalikar, H .

CHEMICAL ENGINEERING SCIENCE, 2003, 58 (01) :19-26

[8] Microreactors for elemental fluorine [J].

Chambers, RD ;

Spink, RCH .

CHEMICAL COMMUNICATIONS, 1999, (10) :883-884

[9]

de Bellefon C, 2000, ANGEW CHEM INT EDIT, V39, P3442, DOI 10.1002/1521-3773(20001002)39:19<3442::AID-ANIE3442>3.0.CO

[10]

2-Q

← 1 2 3 4 →