β3-Adrenoceptor Stimulation on Top of β1-Adrenoceptor Blockade "Stop or Encore?"

被引:23
作者
Balligand, Jean-Luc [1 ]
机构
[1] Catholic Univ Louvain, Unit Pharmacol & Therapeut, B-1200 Brussels, Belgium
关键词
nebivolol; beta3-adrenergic receptor; human heart; contractility; nitric oxide; 3RD-GENERATION BETA-BLOCKER; NITRIC-OXIDE RELEASE; HEART-FAILURE; UP-REGULATION; RECEPTOR; NEBIVOLOL; MYOCARDIUM; ACTIVATION; EXPRESSION; VASORELAXATION;
D O I
10.1016/j.jacc.2009.01.048
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1539 / 1542
页数:4
相关论文
共 35 条
[1]  
BALLIGAND JL, 2009, PHYSL REV IN PRESS
[2]  
BELGE C, 2007, CIRCULATION, V116, P771
[3]   β-1 and β-2 adrenoceptor polymorphisms:: Functional importance, impact on cardiovascular diseases and drug responses [J].
Brodde, Otto-Erich .
PHARMACOLOGY & THERAPEUTICS, 2008, 117 (01) :1-29
[4]   Nebivolol:: A third-generation β-blocker that augments vascular nitric oxide release endothelial β2-adrenergic receptor-mediated nitric oxide production [J].
Broeders, MAW ;
Doevendans, PA ;
Bekkers, BCAM ;
Bronsaer, R ;
van Gorsel, E ;
Heemskerk, JWM ;
Egbrink, MGAO ;
van Breda, E ;
Reneman, RS ;
van der Zee, R .
CIRCULATION, 2000, 102 (06) :677-684
[5]   Upregulation of functional β3-adrenergic receptor in the failing canine myocardium [J].
Cheng, HJ ;
Zhang, ZS ;
Onishi, K ;
Ukai, T ;
Sane, DC ;
Cheng, CP .
CIRCULATION RESEARCH, 2001, 89 (07) :599-606
[6]   Endothelial β3-adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation β-blocker nebivolol [J].
Dessy, C ;
Saliez, J ;
Ghisdal, P ;
Daneau, G ;
Lobysheva, II ;
Frérart, F ;
Belge, C ;
Jnaoui, K ;
Noirhomme, P ;
Feron, O ;
Balligand, JL .
CIRCULATION, 2005, 112 (08) :1198-1205
[7]   Endothelial β3-adrenoceptors mediate vasorelaxation of human coronary microarteries through nitric oxide and endothelium-dependent hyperpolarization [J].
Dessy, C ;
Moniotte, S ;
Ghisdal, P ;
Havaux, X ;
Noirhomme, P ;
Balligand, JL .
CIRCULATION, 2004, 110 (08) :948-954
[8]   The effect of diabetes on expression of β1-, β2-, and β3-adrenoreceptor in rat hearts [J].
Dinçer, ÜD ;
Bidasee, KR ;
Güner, S ;
Tay, A ;
Özçelikay, AT ;
Altan, VM .
DIABETES, 2001, 50 (02) :455-461
[9]   Cardiovascular effects of beta 3-adrenoceptor stimulation in perinephritic hypertension [J].
Donckier, JE ;
Massart, RE ;
Van Mechelen, H ;
Heyndrickx, GR ;
Gauthier, C ;
Balligand, JL .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2001, 31 (08) :681-689
[10]   Progressive hypertrophy and heart failure in β1-adrenergic receptor transgenic mice [J].
Engelhardt, S ;
Hein, L ;
Wiesmann, F ;
Lohse, MJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) :7059-7064