Postantibiotic effects of gatifloxacin against gram-positive and -negative organisms

被引：11

作者：

Pankuch, GA

Jacobs, MR

Appelbaum, PC

机构：

[1] Milton S Hershey Med Ctr, Dept Pathol, Hershey, PA 17033 USA

[2] Case Western Reserve Univ, Cleveland, OH 44106 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 10期

关键词：

D O I：

10.1128/AAC.43.10.2574

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Gatifloxacin pneumococcal, staphylococcal and enterococcal postantibiotic effects (PAEs) were 0.5 to 4.0 h, respectively. For Escherichia coli and Pseudomonas aeruginosa, PAEs were 2.2 to 4.8 h, Pneumococcal, staphylococcal, and enterococcal postantibiotic sub-MIC effects (PA-SMEs) (four times the MICs) were 3.7 to 8.6, 2.3 to 3.8, and 1.6 h, respectively, and E. coli and P. aeruginosa PA-SMEs were greater than or equal to 9.6 and 4.4 h, respectively.

引用

收藏

页码：2574 / 2575

页数：2

相关论文

共 17 条

[1] Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin [J].

Bauernfeind, A .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 (05) :639-651

[2] THE POSTANTIBIOTIC SUB-MIC EFFECT INVITRO AND INVIVO [J].

CARS, O ;

ODENHOLTTORNQVIST, I .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1993, 31 :159-166

[3]

CRAIG W, 1993, EUR J CLIN MICROBI S, V1, P6

[4]

Craig WA, 1996, ANTIBIOTICS LAB MED, P296

[5] Activities of gatifloxacin compared to those of seven other agents against anaerobic organisms [J].

Ednie, LM ;

Jacobs, MR ;

Appelbaum, PC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (09) :2459-2462

[6] Anti-pneumococcal activity of gatifloxacin compared with other quinolone and non-quinolone agents [J].

Hoellman, DB ;

Lin, GR ;

Jacobs, MR ;

Appelbaum, PC .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1999, 43 (05) :645-649

[7] ANTIBACTERIAL PROPERTIES OF AM-1155, A NEW 8-METHOXY QUINOLONE [J].

HOSAKA, M ;

KINOSHITA, S ;

TOYAMA, A ;

OTSUKI, M ;

NISHINO, T .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1995, 36 (02) :293-301

[8] INVITRO AND INVIVO ANTIBACTERIAL ACTIVITIES OF AM-1155, A NEW 6-FLUORO-8-METHOXY QUINOLONE [J].

HOSAKA, M ;

YASUE, T ;

FUKUDA, H ;

TOMIZAWA, H ;

AOYAMA, H ;

HIRAI, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (10) :2108-2117

[9] Comparative in-vitro and in-vivo activity of AM-1155 against anaerobic bacteria [J].

Kato, N ;

Kato, H ;

Tanaka-Bandoh, K ;

Watanabe, K ;

Ueno, K .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 (05) :631-637

[10] THE POSTANTIBIOTIC EFFECT [J].

MACKENZIE, FM ;

GOULD, IM .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1993, 32 (04) :519-537