Angiotensin-converting enzyme gene and diabetes mellitus

被引：52

作者：

Kennon, B ^{[1
]}

Petrie, JR ^{[1
]}

Small, M ^{[1
]}

Connell, JMC ^{[1
]}

机构：

[1] W Glasgow Hosp Univ, NHS Trust, Dept Med & Therapeut, Glasgow, Lanark, Scotland

来源：

DIABETIC MEDICINE | 1999年 / 16卷 / 06期

关键词：

ACE genotype; angiotensin converting enzyme polymorphism; diabetes mellitus; diabetic complications;

D O I：

10.1046/j.1464-5491.1999.00071.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims The association of the insertion/deletion polymorphism in the angiotensin-converting enzyme (ACE) gene with cardiovascular disease and diabetic nephropathy remains a controversial issue. This review aims to give an overview of the research to date assessing the impact uf the ACE polymorphism in Type 1 and Type 2 diabetes mellitus (DM). Methods A systematic review of the literature was performed in the databases of MEDLINE, PubMed and EMBASE fur the key words 'diabetes mellitus','diabetic nephropathy', 'ACE polymorphism' and 'genotype' and relevant articles were considered. Results A meta-analysis assessing the influence of the ACE polymorphism on disease susceptibility demonstrated. significant odds ratios in individuals with the DD genotype for coronary heart disease, myocardial infarction and both diabetic and nondiabetic renal disease. No association was found for left ventricular hypertrophy or hypertension in nondiabetic subjects. Conclusions The ACE polymorphism appears tu have a significant impact on the progression of diabetic nephropathy and may have therapeutic implications fur identifying those individuals resistant to the effects of ACE inhibitors. It also appears to be indicative of an increased vascular risk in diabetic patients; however, larger prospective studies are required to clarify this situation.

引用

页码：448 / 458

页数：11

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