Calcium entry initiates processes that restore a barrier to dye entry in severed earthworm giant axons

被引：17

作者：

Blanchette, AR

Ballinger, ML

Fishman, HM

Bittner, GD ^{[1
]}

机构：

[1] Univ Texas, Dept Zool, Austin, TX 78712 USA

[2] Univ Texas, Med Branch, Dept Physiol & Biophys, Galveston, TX 77555 USA

[3] Univ Texas, Coll Pharm, Austin, TX 78712 USA

[4] Univ Texas, Inst Neurosci, Austin, TX 78712 USA

[5] Univ Texas, Sch Biol Sci, Neurobiol Sect, Austin, TX 78712 USA

来源：

NEUROSCIENCE LETTERS | 1999年 / 272卷 / 03期

基金：

美国国家卫生研究院;

关键词：

axotomy; nerve repair; membrane sealing; calcium-initiated processes; barrier restoration;

D O I：

10.1016/S0304-3940(99)00544-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

After severance, axons can restore structural barriers that are necessary for recovery of their electrical function. In earthworm myelinated axons, such a barrier to dye entry is mediated by many Vesicles and myelin-derived membranous structures. From time-lapse confocal fluorescence and DIC images, we now report that Ca2+ entry and not axonal injury per se initiates the processes that form a dye barrier, as well as the subsequent structural changes in this barrier and associated membranous structures. The time required to restore a dye barrier after transection also depends only on the time of Ca2+ entry. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：147 / 150

页数：4

共 17 条

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[2]

2-8

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