FK506 and the role of the immunophilin FKBP-52 in nerve regeneration

被引：78

作者：

Gold, BG ^{[1
]}

机构：

[1] Oregon Hlth Sci Univ, Ctr Res Occupat & Environm Toxicol, Portland, OR 97201 USA

[2] Oregon Hlth Sci Univ, Dept Cell & Dev Biol, Portland, OR 97201 USA

来源：

DRUG METABOLISM REVIEWS | 1999年 / 31卷 / 03期

关键词：

D O I：

10.1081/DMR-100101940

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this review, I present a brief overview of the immunosuppressant action of FK506 and my discovery that it also accelerates nerve regeneration in the rat peripheral nervous system (for a more detailed review, see Ref. 1). The purpose of the review is to show how studies on the mechanism by which FK506 elicits its neurotrophic activity have lead to the discovery of a novel pathway regulating nerve regeneration. Knowledge of the correct target mediating the neurotrophic activity of the neuroimmunophilin ligands will enable the rationale design of new neurotrophic drugs.

引用

页码：649 / 663

页数：15

共 75 条

[1] OVEREXPRESSION, CHARACTERIZATION, AND PURIFICATION OF A RECOMBINANT MOUSE IMMUNOPHILIN FKBP-52 AND IDENTIFICATION OF AN ASSOCIATED PHOSPHOPROTEIN
ALNEMRI, ES
FERNANDESALNEMRI, T
NELKI, DS
DUDLEY, K
DUBOIS, GC
LITWACK, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) : 6839 - 6843
[2] GAP-43: An intrinsic determinant of neuronal development and plasticity
Benowitz, LI
Routtenberg, A
[J]. TRENDS IN NEUROSCIENCES, 1997, 20 (02) : 84 - 91
[3] Butcher SP, 1997, J NEUROSCI, V17, P6939
[4] FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain
Cameron, AM
Nucifora, FC
Fung, ET
Livingston, DJ
Aldape, RA
Ross, CA
Snyder, SH
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (44) : 27582 - 27588
[5] Comparative effects of FK-506, rapamycin and cyclosporin A, on the in vitro differentiation of dorsal root ganglia explants and septal cholinergic neurons
Carreau, A
Gueugnon, J
Benavides, J
Vigé, X
[J]. NEUROPHARMACOLOGY, 1997, 36 (11-12) : 1755 - 1762
[6] ACTIVATION OF MAP KINASE KINASE IS NECESSARY AND SUFFICIENT FOR PC12 DIFFERENTIATION AND FOR TRANSFORMATION OF NIH 3T3 CELLS
COWLEY, S
PATERSON, H
KEMP, P
MARSHALL, CJ
[J]. CELL, 1994, 77 (06) : 841 - 852
[7] THE HSP56 IMMUNOPHILIN COMPONENT OF UNTRANSFORMED STEROID-RECEPTOR COMPLEXES IS LOCALIZED BOTH TO MICROTUBULES IN THE CYTOPLASM AND TO THE SAME NONRANDOM REGIONS WITHIN THE NUCLEUS AS THE STEROID-RECEPTOR
CZAR, MJ
OWENSGRILLO, JK
YEM, AW
LEACH, KL
DEIBEL, MR
WELSH, MJ
PRATT, WB
[J]. MOLECULAR ENDOCRINOLOGY, 1994, 8 (12) : 1731 - 1741
[8] IMMUNOSUPPRESSANT FK506 ENHANCES PHOSPHORYLATION OF NITRIC-OXIDE SYNTHASE AND PROTECTS AGAINST GLUTAMATE NEUROTOXICITY
DAWSON, TM
STEINER, JP
DAWSON, VL
DINERMAN, JL
UHL, GR
SNYDER, SH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) : 9808 - 9812
[9] Cytoplasmic dynein is associated with slow axonal transport
Dillman, JF
Dabney, LP
Pfister, KK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) : 141 - 144
[10] Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery - The role of p23 is to stabilize receptor-hsp90 heterocomplexes formed by hsp90-p60-hsp70
Dittmar, KD
Demady, DR
Stancato, LF
Krishna, P
Pratt, WB
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (34) : 21213 - 21220

← 1 2 3 4 5 6 7 8 →