Substituted indoloquinolines as new antifungal agents

被引：68

作者：

Ablordeppey, SY ^{[1
]}

Fan, PC

Li, SM

Clark, AM

Hufford, CD

机构：

[1] Florida A&M Univ, Coll Pharm & Pharmaceut Sci, Tallahassee, FL 32307 USA

[2] Univ Mississippi, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, Sch Pharm, University, MS 38677 USA

[3] Univ Mississippi, Dept Pharmacognosy, Sch Pharm, University, MS 38677 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0968-0896(01)00401-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cryptolepine (2) possesses desirable properties to serve as a lead in developing new antifungal agents. Using SAR techniques, several analogues of cryptolepine were designed to increase potency and to broaden the antifungal spectrum over several opportunistic microorganisms. A number of 2-substituted indoloquinolines have been synthesized and evaluated in antifungal screens and several have been shown to increase potency and expand the antifungal spectrum of cryptolepine. Comparison of MICs of a number of these analogues with standard antifungal agents, shows them to be comparable to Amphotericin B and Ketoconazole. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1337 / 1346

页数：10

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