Angiogenesis, protein and gene delivery

被引：14

作者：

Azrin, M ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Div Cardiol, Farmington, CT 06030 USA

来源：

BRITISH MEDICAL BULLETIN | 2001年 / 59卷

关键词：

D O I：

10.1093/bmb/59.1.211

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Advances in our understanding of angiogenesis and blood vessel growth have given rise to efforts to develop novel therapeutic approaches for patients with ischaemia who are not adequately treated with presently available therapies. Among the growth factors that play a role in blood vessel growth and development, vascular endothelial growth factors and fibroblast growth factors have been the most extensively studied. Various methods of delivery have been utilized to enhance localization and persistence, including methods for delivery of proteins as well as gene transfer techniques. Initial clinical trials have now been undertaken. Preliminary information on efficacy is beginning to become available, raising hopes, as well as questions about the future direction and potential success of therapeutic angiogenesis as a clinical approach to the treatment of ischaemia.

引用

页码：211 / 225

页数：15

共 44 条

[1] Lower-extremity edema associated with gene transfer of naked DNA encoding vascular endothelial growth factor [J].