Retrograde transport on the COG railway

被引：109

作者：

Ungar, D

Oka, T

Krieger, M

Hughson, FM

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

[2] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

[3] Kyushu Univ, Grad Sch Med Sci, Dept Mol Biol, Fukuoka 8128582, Japan

来源：

TRENDS IN CELL BIOLOGY | 2006年 / 16卷 / 02期

关键词：

D O I：

10.1016/j.tcb.2005.12.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The conserved oligomeric Golgi (COG) complex is essential for establishing and/or maintaining the structure and function of the Golgi apparatus. The Golgi apparatus, in turn, has a central role in protein sorting and glycosylation within the eukaryotic secretory pathway. As a consequence, COG mutations can give rise to human genetic diseases known as congenital disorders of glycosylation. We review recent results from studies of yeast, worm, fly and mammalian COG that provide evidence that COG might function in retrograde vesicular trafficking within the Golgi apparatus. This hypothesis explains the impact of COG mutations by postulating that they impair the retrograde flow of resident Golgi proteins needed to maintain normal Golgi structure and function.

引用

收藏

页码：113 / 120

页数：8

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