New-onset seizure associated with quetiapine and olanzapine

被引：27

作者：

Hedges, DW

Jeppson, KG ^{[1
]}

机构：

[1] Utah State Hosp, Provo, UT 84603 USA

[2] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA

[3] Brigham Young Univ, Ctr Neurosci, Provo, UT 84602 USA

[4] Brigham Young Univ, Ctr Neurosci, Provo, UT 84602 USA

来源：

ANNALS OF PHARMACOTHERAPY | 2002年 / 36卷 / 03期

关键词：

atypical antipsychotics; olanzapine; quetiapine; seizure;

D O I：

10.1345/aph.1A207

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

OBJECTIVE: To report a case involving a witnessed seizure in a patient receiving concurrent olanzapine and quetiapine. CASE SUMMARY: A 27-year-old white woman was observed to have a seizure while receiving a stable dosage of olanzapine 15 mg/d, with the addition of quetiapine 100 mg in the evening 1 day before the occurrence of the seizure. There were no known risk factors for epilepsy. DISCUSSION: This case reports a new-onset seizure in the context of concurrent olanzapine and quetiapine use. Interpretation is complicated by recent discontinuation of low-dose clonazepam. CONCLUSIONS: While uncommon, seizures can occur with non-clozapine atypical antipsychotics. Caution is indicated when using these drugs with other agents that may lower the seizure threshold.

引用

页码：437 / 439

页数：3

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