The Hippo pathway and human cancer

被引：1681

作者：

Harvey, Kieran F. ^{[1
,2
,3
]}

Zhang, Xiaomeng ^{[1
,2
,3
]}

Thomas, David M. ^{[1
,2
,3
]}

机构：

[1] Peter MacCallum Canc Ctr, East Melbourne, Vic 3002, Australia

[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3010, Australia

[3] Univ Melbourne, Dept Pathol, Parkville, Vic 3010, Australia

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 04期

基金：

英国医学研究理事会;

关键词：

YES-ASSOCIATED PROTEIN; TUMOR-SUPPRESSOR PATHWAY; STEM-CELL PROLIFERATION; TISSUE-GROWTH; SIZE-CONTROL; ORGAN SIZE; PROMOTER HYPERMETHYLATION; CONTACT INHIBITION; YAP ONCOPROTEIN; DOWN-REGULATION;

D O I：

10.1038/nrc3458

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The Hippo pathway controls organ size in diverse species, whereas pathway deregulation can induce tumours in model organisms and occurs in a broad range of human carcinomas, including lung, colorectal, ovarian and liver cancer. Despite this, somatic or germline mutations in Hippo pathway genes are uncommon, with only the upstream pathway gene neurofibromin 2 (NF2) recognized as a bona fide tumour suppressor gene. In this Review, we appraise the evidence for the Hippo pathway as a cancer signalling network, and discuss cancer-relevant biological functions, potential mechanisms by which Hippo pathway activity is altered in cancer and emerging therapeutic strategies.

引用

页码：246 / 257

页数：12

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