Highly enantioselective synthesis of γ-hydroxy-α,β-acetylenic esters by asymmetric alkyne addition to aldehydes

被引：114

作者：

Gao, G

Wang, Q

Yu, XQ ^{[1
]}

Xie, RG

Pu, L

机构：

[1] Sichuan Univ, Dept Chem, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

[2] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 01期

关键词：

aldehydes; alkynes; asymmetric synthesis; binol ligands; esters;

D O I：

10.1002/anie.200500469

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Alkynoates are added to aromatic and α,β-unsaturated aldehydes in the synthesis of the title compounds in optically active form. This highly enantioselective and useful method is carried out under mild reaction conditions and employs the readily available chiral 1,1′-bi-2-naphthol (binol) ligand and the metal reagents Et2Zn and [Ti(OiPr)4] (see scheme; HMPA = hexamethylphosphoramide). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：122 / 125

页数：4

共 38 条

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