Macrophage-Associated Mesenchymal Stem Cells Assume an Activated, Migratory, Pro-Inflammatory Phenotype with Increased IL-6 and CXCL10 Secretion

被引：105

作者：

Anton, Kevin ^{[1
]}

Banerjee, Debabrata ^{[1
,2
]}

Glod, John ^{[1
,3
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, Dept Pharmacol, New Brunswick, NJ USA

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Med, Canc Inst New Jersey, New Brunswick, NJ 08903 USA

[3] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pediat, Canc Inst New Jersey, New Brunswick, NJ 08903 USA

来源：

PLOS ONE | 2012年 / 7卷 / 04期

关键词：

MONOCYTE CHEMOTACTIC PROTEIN-1; BONE-MARROW; TUMOR STROMA; DELIVERY VEHICLES; TARGETED-DELIVERY; INFILTRATION; CANCER; KINASE; DIFFERENTIATION; PROLIFERATION;

D O I：

10.1371/journal.pone.0035036

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mesenchymal stem cells (MSCs) exhibit tropism for sites of tissue injury and tumors. However, the influence of the microenvironment on MSC phenotype and localization remains incompletely characterized. In this study, we begin to define a macrophage-induced MSC phenotype. These MSCs secrete interleukin-6 (IL-6), CCL5, and interferon gamma-induced protein-10 (CXCL10) and exhibit increased mobility in response to multiple soluble factors produced by macrophages including IL-8, CCL2, and CCL5. The pro-migratory phenotype is dependent on activation of a c-Jun N-terminal kinase (JNK) pathway. This work begins to identify the influence of macrophages on MSC biology. These interactions are likely to play an important role in the tissue inflammatory response and may provide insight into the migratory potential of MSCs in inflammation and tissue injury.

引用

页数：10

共 53 条

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