Delayed image of iodine-123 iomazenil as a relative map of benzodiazepine receptor binding: The optimal scan time

被引:21
作者
Onishi, Y
Yonekura, Y
Tanaka, F
Nishizawa, S
Okazawa, H
Ishizu, K
Fujita, T
Konishi, J
Mukai, T
机构
[1] FUKUI MED SCH,FUKUI 91011,JAPAN
[2] KYOTO UNIV,SCH MED,KYOTO,JAPAN
[3] KYOTO COLL MED TECHNOL,KYOTO,JAPAN
来源
EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1996年 / 23卷 / 11期
关键词
iodine-123; iomazenil; single-photon emission tomography; benzodiazepine receptor imaging; delayed SPECT image;
D O I
10.1007/BF01254474
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
''Delayed'' single-photon emission tomograpic (SPET) images after an intravenous bolus injection of iodine-123 iomazenil have been used as a relative map of benzodiazepine receptor binding. We determined the optimal scan time for obtaining such a map and assessed the errors of the map. SPET and blood data from six healthy volunteers and five patients were used. A three-compartment kinetic model was employed in simulation studies and analyses of actual data. The simulation studies suggested that, in the normal brain, the scan time at which a single SPET Image best represented the relative receptor binding was 3.0-3.5 h post-injection, This finding was supported by actual data from the volunteers, The simulation studies also suggested that the optimal scan time was not greatly changed by the variability of the input functions, and that the error in the SPET image contrast in the vicinity of the optimal scan time was not increased by changes in the tracer kinetics in the entire brain. The SPET image contrast in the patients at 3.0 h post-injection agreed well with the reference receptor binding estimated by kinetic analysis, with a mean error of 3.6%, These findings support the use of a single SPET image after bolus injection of [I-123]iomazenil as a relative map of benzodiazepine receptor binding. For this purpose, a SPET scan time of 3.0-3.5 h post-injection is recommended.
引用
收藏
页码:1491 / 1497
页数:7
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