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Enteropathogenic Escherichia coli: foe or innocent bystander?

被引：133
作者：
Hu, J. [1 ]
Torres, A. G. [1 ,2 ,3 ]
机构：
[1] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA
[2] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA
[3] Univ Texas Med Branch, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2015年 / 21卷 / 08期
关键词：
Asymptomatic pathogenic Escherichia coli; atypical EPEC; diarrhoea; enteropathogenic Escherichia coli; epidemiology; DNA MICROARRAY ANALYSIS; HUMAN COLOSTRUM; DEVELOPING-COUNTRIES; PROLONGED DIARRHEA; ENTERIC PATHOGENS; IN-VITRO; VIRULENCE; CHILDREN; STRAINS; EPEC;
D O I：
10.1016/j.cmi.2015.01.015
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Enteropathogenic Escherichia coli (EPEC) remain one the most important pathogens infecting children and they are one of the main causes of persistent diarrhoea worldwide. Historically, typical EPEC (tEPEC), defined as those isolates with the attaching and effacement (A/E) genotype (eae(+)), which possess bfpA(+) and lack the stx(-) genes are found strongly associated with diarrhoea! cases. However, occurrence of atypical EPEC (aEPEC; eae(+) bfpA(-) stx(-)) in diarrhoeal and asymptomatic hosts has made investigators question the role of these pathogens in human disease. Current epidemiological data are helping to answer the question of whether EPEC is mainly a foe or an innocent bystander during infection. Clinical Microbiology and Infection (C) 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：729 / 734
页数：6
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