Encephalitis after hepatitis B vaccination - Recurrent disseminated encephalitis or MS?

被引：79

作者：

Tourbah, A

Gout, O

Liblau, R

Lyon-Caen, O

Bougniot, C

Iba-Zizen, MT

Cabanis, EA

机构：

[1] Hop La Pitie Salpetriere, Federat Neurol, F-75651 Paris, France

[2] Hop La Pitie Salpetriere, Lab Immunol Cellulaire, F-75651 Paris, France

[3] Hop La Pitie Salpetriere, CJF Pathol Myeline 9711, F-75651 Paris, France

[4] Fac Med Pitie Salpetriere Paris VI, Paris, France

[5] Ctr Hosp Natl Ophtalmol Quinze Vingts, Serv Neuroradiol, Paris, France

[6] Fdn A Rothschild, Serv Neurol, Paris, France

来源：

NEUROLOGY | 1999年 / 53卷 / 02期

关键词：

D O I：

10.1212/WNL.53.2.396

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To describe clinical and MRI features of patients with a disease suggestive of CNS inflammation after hepatitis B vaccination. Methods: Eight patients with confirmed CNS inflammation occurring less than 10 Reeks after hepatitis B vaccination are described. They received follow-up clinically and on MRI for a mean period of 18 months. Results: Clinical and MRI findings were compatible with acute disseminated encephalomyelitis. However, clinical follow-up, repeated MRI, or both showed the persistence of inflammatory activity, which makes this encephalitis more suggestive of MS than of acute disseminated encephalomyelitis. Conclusion: The persistent inflammatory activity observed clinically and on MRI in these patients is comparable with that usually observed in RIS, Epidemiologic studies are currently testing the hypothesis of a triggering role of hepatitis B vaccination in CNS demyelination.

引用

页码：396 / 401

页数：6

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