Phosphonate analogues of peptide nucleic acids and related compounds: Synthesis and hybridization properties

被引：17

作者：

Efimov, VA ^{[1
]}

Buryakova, AA ^{[1
]}

Choob, MV ^{[1
]}

Chakhmakhcheva, OG ^{[1
]}

机构：

[1] Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117871, Russia

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 6-7期

关键词：

D O I：

10.1080/07328319908044728

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of a set of novel chimeric oligomers representing PNA and phosphono-PNA analogues has been accomplished, and their binding affinity to complementary DNA and RNA strands was evaluated.

引用

页码：1393 / 1396

页数：4

共 5 条

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Efimov, VA ;

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Chakhmakhcheva, OG .

NUCLEIC ACIDS RESEARCH, 1998, 26 (02) :566-575

[2] RAPID SYNTHESIS OF LONG-CHAIN DEOXYRIBOOLIGONUCLEOTIDES BY THE N-METHYLIMIDAZOLIDE PHOSPHOTRIESTER METHOD [J].

EFIMOV, VA ;

BURYAKOVA, AA ;

REVERDATTO, SV ;

CHAKHMAKHCHEVA, OG ;

OVCHINNIKOV, YA .

NUCLEIC ACIDS RESEARCH, 1983, 11 (23) :8369-8387

[3]

Efimov VA, 1996, COLLECT CZECH CHEM C, V61, pS262

[4]

Efimov VA, 1998, BIOORG KHIM+, V24, P696

[5] An approach towards the synthesis of oligomers containing a N-2-hydroxyethyl-aminomethylphosphonate backbone: A novel PNA analogue [J].

vanderLaan, AC ;

Stromberg, R ;

vanBoom, JH ;

KuylYeheskiely, E ;

Efimov, VA ;

Chakhmakhcheva, OG .

TETRAHEDRON LETTERS, 1996, 37 (43) :7857-7860

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