Cytokines driving breast cancer stemness

被引：70

作者：

Chin, Andrew R. ^{[1
,2
]}

Wang, Shizhen Emily ^{[1
]}

机构：

[1] City Hope Natl Med Ctr, Beckman Res Inst, Dept Canc Biol, Duarte, CA 91010 USA

[2] City Hope Natl Med Ctr, Irell & Manella Grad Sch Biol Sci, Duarte, CA 91010 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2014年 / 382卷 / 01期

关键词：

Cancer stem cells; Tumor microenvironment; Cytokines; IL-6; IL-8; CCL2; MONOCYTE CHEMOATTRACTANT PROTEIN-1; SIGNALING PATHWAY; GENE-EXPRESSION; SOLID TUMORS; IN-VITRO; CELLS; IDENTIFICATION; INTERLEUKIN-8; FIBROBLASTS; GROWTH;

D O I：

10.1016/j.mce.2013.03.024

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

There is increasing evidence for the cancer stem cell model in which a subset of cancer cells possessing stem cell properties, referred to as tumor-initiating or cancer stem-like cells (CSCs), play crucial roles in multiple aspects of cancer. Recent studies have started to characterize the crucial role of various cytokines in the tumor microenvironment in regulating the fate of CSCs. In this review, we summarized some of the latest findings on cytokines that drive breast cancer sternness and their mechanisms of action. These cytokines, including IL-6, IL-8, CCL2 and TGF-beta, are frequently elevated in breast tumors and may hold promise as potential therapeutic targets to eradicate CSCs. In combination with conventional chemotherapy and radiotherapy targeting rapidly proliferating cancer cells, intervention of the cancer sternness-driving cytokines may achieve additional benefits for breast cancer patients by suppressing CSC-promoted cancer progression, recurrence, and drug refractoriness. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：598 / 602

页数：5

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