Structures of the lectins from Pseudomonas aeruginosa:: insights into the molecular basis for host glycan recognition

被引:246
作者
Imberty, A
Wimmerová, M
Mitchell, EP
Gilboa-Garber, N
机构
[1] Univ Grenoble 1, CNRS, CERMAV, F-38041 Grenoble 9, France
[2] Masaryk Univ, Natl Ctr Biomol Res, Dept Biochem, CS-61137 Brno, Czech Republic
[3] Masaryk Univ, Dept Biochem, CS-61137 Brno, Czech Republic
[4] European Synchrotron Radiat Facil, Expt Div, F-38043 Grenoble, France
[5] Bar Ilan Univ, Fac Life Sci, IL-52900 Ramat Gan, Israel
关键词
Pseudomonas aeruginosa; lectins; oligosaccharides; PA-IL; PA-IIL;
D O I
10.1016/j.micinf.2003.10.016
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The opportunistic human pathogen Pseudomonas aeruginosa produces two lectins in close association with virulence factors: PA-IL and PA-IIL, which bind to galactose- and fucose/matmose-containing glycoconjugates, respectively. We review here the structural aspects of these lectins relative to their putative roles in host recognition, cell surface adhesion and biofilm formation. (C) 2003 Elsevier SAS. All rights reserved.
引用
收藏
页码:221 / 228
页数:8
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