Protective Effect of 4-Methoxy-5-hydroxycanthin-6-one, A Natural Alkaloid, on Dextran Sulfate Sodium-Induced Rat Colitis

被引：39

作者：

Liu, Jun-Feng ^{[1
,3
]}

Shao, Meng ^{[2
,3
]}

Zhai, Da-Wei ^{[3
]}

Liu, Ke ^{[4
]}

Wu, Li-Jun ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Med, Shenyang 110016, Peoples R China

[2] Jilin Univ, Coll life Sci, Changchun, Jilin, Peoples R China

[3] Shandong Target Drug Res Co Ltd, Shandong, Peoples R China

[4] Yantai Univ, Sch Pharm, Yantai, Shandong, Peoples R China

来源：

PLANTA MEDICA | 2009年 / 75卷 / 02期

关键词：

ulcerative colitis; DSS; Picrasma quassioides (D. Don) Benn; Simaroubaceae; MPO; TNF-alpha; 4-methoxy-5-hydroxycanthin-6-one; INTESTINAL INFLAMMATION; ULCERATIVE-COLITIS; MODELS; MICE;

D O I：

10.1055/s-0028-1088390

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

In the present study, we evaluated the effect of 4-methoxy-5-hydroxycanthin-6-one (CAN), a natural alkaloid isolated from Picrasma quassioides (D.Don) Benn., on ulcerative colitis induced by dextran sulfate sodium (DSS) in rats in comparison with the positive control drug, sulfasalazine (SASP). Given orally for several days, CAN significantly reduced the severity of colitis and mitigated changes in colon length, colon mucosa myeloperoxidase (MPO) activity, and the level of tumor necrosis factor-alpha (TNF-alpha) in serum. The effect of CAN was similar to that of SASP. These results suggest that CAN treatment might be an effective therapeutic intervention against ulcerative colitis induced by DSS.

引用

页码：142 / 145

页数：4

共 19 条

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