The fluorinase from Streptomyces cattleya is also a chlorinase

被引：77

作者：

Deng, H

Cobb, SL

McEwan, AR

McGlinchey, RP

Naismith, JH

O'Hagan, D ^{[1
]}

Robinson, DA

Spencer, JB

机构：

[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland

[2] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland

[3] Univ Cambridge, Chem Labs, Cambridge CB2 1EW, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

chlorinase; enzyme catalysis; fluorinase; halogenation; S-adenosylmethionine;

D O I：

10.1002/anie.200503582

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Choices choices: The fluorinase enzyme from Streptomyces cattleya (catalyzes the formation of a C-F bond from fluoride ions) also has the capacity to utilize a chloride ion although it has a clear preference for the fluoride ion. The enzyme mediates a nucleophilic chlorination reaction, which is an unusual mechanism for enzymatic chlorination. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：759 / 762

页数：4

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