Synthesis and estrogen receptor binding affinities of the major human metabolites of raloxifene (LY139481)

被引:13
作者
Dodge, JA
Lugar, CW
Cho, S
Osborne, JJ
Phillips, DL
Glasebrook, AL
Frolik, CA
机构
[1] Lilly Research Laboratories, Eli Lilly and Company, Indianapolis
关键词
D O I
10.1016/S0960-894X(97)00142-X
中图分类号
R914 [药物化学];
学科分类号
100701 [药物化学];
摘要
Glucuronide conjugates 1 and 2, the major metabolites of raloxifene, have been prepared and their molecular interactions with the estrogen receptor determined. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:993 / 996
页数:4
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