Association of plasma homocysteine with the number of major coronary arteries severely narrowed

被引：42

作者：

Schynder, G

Pin, R

Roffi, M

Flammer, Y

Hess, OM

机构：

[1] Univ Calif San Diego, Med Ctr, Div Cardiol, John Ross Cardiac Catheterizat Lab, San Diego, CA 92103 USA

[2] Swiss Cardiovasc Ctr, Div Cardiol, Bern, Switzerland

[3] Univ Hosp Bern, Bern, Switzerland

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2001年 / 88卷 / 09期

关键词：

D O I：

10.1016/S0002-9149(01)01983-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This cross-sectional study of 631 patients with 1,519 treated stenoses established that total plasma homocysteine, together with age and gender, is a strong predictor of the severity of coronary artery disease. Thus, total plasma homocysteine is an independent cardiovascular marker that should be assessed in the evaluation of a patient's cardiovascular risk profile.

引用

收藏

页码：1027 / +

页数：5

相关论文

共 20 条

[1] RELATION OF SERUM HOMOCYSTEINE AND LIPOPROTEIN(A) CONCENTRATIONS TO ATHEROSCLEROTIC DISEASE IN A PROSPECTIVE FINNISH POPULATION-BASED STUDY [J].

ALFTHAN, G ;

PEKKANEN, J ;

JAUHIAINEN, M ;

PITKANIEMI, J ;

KARVONEN, M ;

TUOMILEHTO, J ;

SALONEN, JT ;

EHNHOLM, C .

ATHEROSCLEROSIS, 1994, 106 (01) :9-19

[2] A QUANTITATIVE ASSESSMENT OF PLASMA HOMOCYSTEINE AS A RISK FACTOR FOR VASCULAR-DISEASE - PROBABLE BENEFITS OF INCREASING FOLIC-ACID INTAKES [J].

BOUSHEY, CJ ;

BERESFORD, SAA ;

OMENN, GS ;

MOTULSKY, AG .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (13) :1049-1057

[3] The graded effect of hyperhomocysteinemia on the severity and extent of coronary atherosclerosis [J].

Chao, CL ;

Tsai, HH ;

Lee, CM ;

Hsu, SM ;

Kao, JT ;

Chien, KL ;

Sung, FC ;

Lee, YT .

ATHEROSCLEROSIS, 1999, 147 (02) :379-386

[4]

ChasanTaber L, 1996, J AM COLL NUTR, V15, P136

[5] Serial measures of plasma homocyst(e)ine after acute myocardial infarction [J].

Egerton, W ;

Silberberg, J ;

Crooks, R ;

Ray, C ;

Xie, LJ ;

Dudman, N .

AMERICAN JOURNAL OF CARDIOLOGY, 1996, 77 (09) :759-&

[6] Homocyst(e)ine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial [J].

Evans, RW ;

Shaten, BJ ;

Hempel, JD ;

Cutler, JA ;

Kuller, LH .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (10) :1947-1953

[7] Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins - The atherosclerosis risk in communities (ARIC) study [J].

Folsom, AR ;

Nieto, FJ ;

McGovern, PG ;

Tsai, MY ;

Malinow, MR ;

Eckfeldt, JH ;

Hess, DL ;

Davis, CE .

CIRCULATION, 1998, 98 (03) :204-210

[8] HOMOCYSTEINE, A RISK FACTOR FOR PREMATURE VASCULAR-DISEASE AND THROMBOSIS, INDUCES TISSUE FACTOR ACTIVITY IN ENDOTHELIAL-CELLS [J].

FRYER, RH ;

WILSON, BD ;

GUBLER, DB ;

FITZGERALD, LA ;

RODGERS, GM .

ARTERIOSCLEROSIS AND THROMBOSIS, 1993, 13 (09) :1327-1333

[9] Tissue plasminogen activator binding to the annexin II tail domain - Direct modulation by homocysteine [J].

Hajjar, KA ;

Mauri, L ;

Jacovina, AT ;

Zhong, FM ;

Mirza, UA ;

Padovan, JC ;

Chait, BT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (16) :9987-9993

[10] Homocysteine and cardiovascular disease [J].

Refsum, H ;

Ueland, PM ;

Nygård, O ;

Vollset, SE .

ANNUAL REVIEW OF MEDICINE, 1998, 49 :31-62