A practical manufacturing synthesis of 1-(R)-hydroxymethyl-DTPA: An important intermediate in the synthesis of MRI contrast agents

被引：14

作者：

Amedio, JC ^{[1
]}

Bernard, PJ ^{[1
]}

Fountain, M ^{[1
]}

Van Wagenen, G ^{[1
]}

机构：

[1] EPIX Med Inc, Chem Dev, Cambridge, MA 02142 USA

来源：

SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 14期

关键词：

D O I：

10.1080/00397919908086243

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of alcohol 2 is described from L-Serine (OMe) in four synthetic steps. The process uses readily available reagents and is suitable for manufacturing.

引用

页码：2377 / 2391

页数：15

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