Generation of influenza A virus from cloned cDNAs - historical perspective and outlook for the new millenium

被引：17

作者：

Neumann, G

Kawaoka, Y

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol,Minato Ku, Tokyo 1088639, Japan

[2] Univ Wisconsin, Sch Vet Edicine, Dept Pathobiol Sci, Madison, WI USA

来源：

REVIEWS IN MEDICAL VIROLOGY | 2002年 / 12卷 / 01期

关键词：

D O I：

10.1002/rmv.332

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Influenza virus reverse genetics has reached a level of sophistication where one can confidently generate virus entirely from cloned DNAs. The new systems makes it feasible to study the molecular mechanisms of virus replication and pathogenicity, as well as to generate attenuated live virus vaccines, gene delivery vehicles, and possibly other RNA viruses from cloned cDNAs. During the next decade, one can anticipate the translation of influenza virus reverse genetics into biomedically relevant advances. Copyright (C) 2002 John Wiley Sons, Ltd.

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页码：13 / 30

页数：18

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