2-cyanopyrrolidides as potent, stable inhibitors of dipeptidyl peptidase IV

被引：86

作者：

Ashworth, DM ^{[1
]}

Atrash, B ^{[1
]}

Baker, GR ^{[1
]}

Baxter, AJ ^{[1
]}

Jenkins, PD ^{[1
]}

Jones, DM ^{[1
]}

Szelke, M ^{[1
]}

机构：

[1] CHILWORTH RES CTR,FERRING RES INST,SOUTHAMPTON,HANTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 10期

关键词：

D O I：

10.1016/0960-894X(96)00190-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of stable, potent inhibitors of dipeptidyl peptidase IV has been developed. A number of dipeptide analogues, incorporating a 2-cyanopyrrolidide, were found to have K-i values of less than 5 nM versus human DP-IV and half-lives of >48h in aqueous solution (pH 7.4). (C) 1996 Elsevier Science Ltd

引用

页码：1163 / 1166

页数：4

共 17 条

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