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Can Intermittent Dosing Optimize Prolonged Linezolid Treatment of Difficult Multidrug-Resistant Tuberculosis?

被引：40
作者：
Chang, Kwok-Chiu [1 ]
Yew, Wing-Wai [2 ]
Cheung, Siu-Wai [3 ]
Leung, Chi-Chiu [1 ]
Tam, Cheuk-Ming [1 ]
Chau, Chi-Hung [4 ]
Wen, Peter Kin-Ho [4 ]
Chan, Raphael Chiu-Yeung [2 ]
机构：
[1] Dept Hlth, TB & Chest Serv, Hong Kong, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China
[3] Prince Wales Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China
[4] Grantham Hosp, TB & Chest Unit, Hong Kong, Hong Kong, Peoples R China
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 07期
关键词：
MYCOBACTERIUM-TUBERCULOSIS; PHARMACOKINETICS; PNU-100480; ASSAY; SERUM;
D O I：
10.1128/AAC.00388-13
中图分类号：
Q93 [微生物学];
学科分类号：
071005 [微生物学];
摘要：
We evaluated treatment with linezolid, dosed at 800 mg once daily for 1 to 4 months as guided by sputum culture status and tolerance and then at 1,200 mg thrice weekly until >= 1 year after culture conversion, in addition to individually optimized regimens among 10 consecutive patients with extensively drug-resistant tuberculosis or fluoroquinolone-resistant multidrug-resistant tuberculosis. All achieved stable cure, with anemia corrected and neuropathy stabilized, ameliorated, or avoided after switching to intermittent dosing. Serum linezolid profiles appeared better optimized.
引用
收藏
页码：3445 / 3449
页数：5
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