Methanesulfonic Acid/SiO2 as an Efficient Combination for the Synthesis of 2-Substituted Aromatic and Aliphatic Benzothiazoles from Carboxylic Acids

被引：82

作者：

Sharghi, Hashem ^{[1
]}

Asemani, Omid ^{[2
,3
]}

机构：

[1] Shiraz Univ, Dept Chem, Shiraz 71454, Iran

[2] Shiraz Univ Med Sci, Fac Pharm, Dept Med Chem, Shiraz, Iran

[3] Shiraz Univ Med Sci, Res Ctr, Shiraz, Iran

来源：

SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 05期

关键词：

2-Alkylbenzothiazoles; 2-arylbenzothiazoles; methanesulfonic acid; silica gel; ANTITUMOR BENZOTHIAZOLES; BIOLOGICAL-PROPERTIES; 2-ARYLBENZOTHIAZOLES; 2-(4-AMINOPHENYL)BENZOTHIAZOLES; BENZOXAZOLES; AMA; REARRANGEMENT; DERIVATIVES; REAGENT; AGENTS;

D O I：

10.1080/00397910802431214

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methanesulfonic acid/SiO2 (1mL/0.3g) was found to be as an expeditious mixture in the synthesis of 2-substituted aromatic and aliphatic benzothiazoles at 140C using carboxylic acids. After a simple workup, benzothiazoles were obtained in good yields. Simplicity, use of widely available and diverse carboxylic acids, and easy handling of the reaction conditions are among the benefits of the method.

引用

页码：860 / 867

页数：8

共 22 条

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[2]

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