Effects of hydroxystyrene on the expression of the inflammatory cytokine genes and their content in macrophages tolerant to endotoxin

被引：2

作者：

Dushkin, MI

Vereshchagin, EI

Grebenshchikov, AY

Safina, AF

Shvarts, YS

机构：

[1] Russian Acad Med Sci, Inst Therapy, Siberian Div, Moscow 109801, Russia

[2] Russian Acad Med Sci, Inst Clin Immunol, Siberian Div, Moscow 109801, Russia

[3] Russian Acad Med Sci, Inst Med, Moscow 109801, Russia

[4] Russian Acad Med Sci, Inst Clin & Expt Lymphol, Siberian Div, Moscow 109801, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1999年 / 127卷 / 01期

关键词：

hydroxystyrenes; cytokines; endotoxin tolerance; macrophages;

D O I：

10.1007/BF02432803

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Preincubation of resident macrophages with 25-hydroxycholesterol decreased the lipopolysaccharide-induced expression of mRNAs of tumor necrosis factor and interleukin-1, while 7-ketocholesterol stimulated the expression of the tumor necrosis factor mRNA. Tolerant macrophages characterized by decreased tumor necrosis factor secretion in response to lipopolysaccharide have increased (in comparison with resident macrophages) content of 25- and 27-hydroxycholesterol.

引用

页码：63 / 65

页数：3

共 15 条

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ABRAMOV VV, 1995, B SIBIRSK OTDELENIYA, V1, P60

[2] ATHEROSCLEROSIS AND STEROL 27-HYDROXYLASE - EVIDENCE FOR A ROLE OF THIS ENZYME IN ELIMINATION OF CHOLESTEROL FROM HUMAN MACROPHAGES [J].