Lack of evidence for human-to-human transmission of avian influenza A (H9N2) viruses in Hong Kong, China, 1999

被引:77
作者
Uyeki, TM
Chong, YH
Katz, JM
Lim, W
Ho, YY
Wang, SS
Tsang, THF
Au, WWY
Chan, SC
Rowe, T
Hu-Primmer, J
Bell, JC
Thompson, WW
Bridges, CB
Cox, NJ
Mak, KH
Fukuda, K
机构
[1] CDCP, Natl Ctr Infect Dis, Div Viral & Rickettsial Dis, Influenza Branch, Atlanta, GA 30333 USA
[2] Hong Kong Special Adm Reg, Dept Hlth, Hong Kong, Hong Kong, Peoples R China
关键词
D O I
10.3201/eid0802.010148
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In April 1999, isolation of avian influenza A (H9N2) viruses from humans was confirmed for the first time. H9N2 viruses were isolated from nasopharyngeal aspirate specimens collected from two children who were hospitalized with uncomplicated, febrile, upper respiratory tract illnesses in Hong Kong during March 1999. Novel influenza viruses have the potential to initiate global pandemics if they are sufficiently transmissible among humans. We conducted four retrospective cohort studies of persons exposed to these two H9N2 patients to assess whether human-to-human transmission of avian H9N2 viruses had occurred. No serologic evidence of H9N2 infection was found in family members or health-care workers who had close contact with the H9N2-infected children, suggesting that these H9N2 viruses were not easily transmitted from person to person.
引用
收藏
页码:154 / 159
页数:6
相关论文
共 24 条
  • [1] Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong Kong
    Bridges, CB
    Katz, JM
    Seto, WH
    Chan, PKS
    Tsang, D
    Ho, W
    Mak, KH
    Lim, W
    Tam, JS
    Clarke, M
    Williams, SG
    Mounts, AW
    Bresee, JS
    Conn, LA
    Rowe, T
    Hu-Primmer, J
    Abernathy, RA
    Lu, XH
    Cox, NJ
    Fukuda, K
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (01) : 344 - 348
  • [2] *CDCP, 1998, MMWR-MORBID MORTAL W, V46, P1245
  • [3] Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus
    Claas, ECJ
    Osterhaus, ADME
    van Beek, R
    De Jong, JC
    Rimmelzwaan, GF
    Senne, DA
    Krauss, S
    Shortridge, KF
    Webster, RG
    [J]. LANCET, 1998, 351 (9101) : 472 - 477
  • [4] New clues to the emergence of flu pandemics
    Claas, ECJ
    Osterhaus, ADME
    [J]. NATURE MEDICINE, 1998, 4 (10) : 1122 - 1123
  • [5] Influenza
    Cox, NJ
    Fukuda, K
    [J]. INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 1998, 12 (01) : 27 - +
  • [6] EICK A, 2000, INT C EM INF DIS 200
  • [7] Gou Y, 2000, Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, V14, P209
  • [8] Molecular characterization of H9N2 influenza viruses: Were they the donors of the "internal" genes of H5N1 viruses in Hong Kong?
    Guan, Y
    Shortridge, KF
    Krauss, S
    Webster, RG
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) : 9363 - 9367
  • [9] Guo Y, 1999, Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, V13, P105
  • [10] Characterization of the pathogenicity of members of the newly established H9N2 influenza virus lineages in Asia
    Guo, YJ
    Krauss, S
    Senne, DA
    Mo, IP
    Lo, KS
    Xiong, XP
    Norwood, M
    Shortridge, KF
    Webster, RG
    Guan, Y
    [J]. VIROLOGY, 2000, 267 (02) : 279 - 288