Synthesis and antiviral activity of some N-benzenesulphonylbenzimidazoles.

被引：64

作者：

Garuti, L

Roberti, M

Cermelli, C

机构：

[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy

[2] Univ Modena, Dept Hyg Microbiol & Biostat, I-41100 Modena, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(99)00429-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some N-sulphonylated benzimidazoles were synthesized as potential antiviral agents. Compound 16b and, to a lesser extent, 19b showed activity against two RNA viruses at micromolar concentrations. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2525 / 2530

页数：6

共 22 条

[1]

ALCALDE E, 1993, CHEM PHARM BULL, V41, P614

[2]

ALCALDE E, 1992, SYNTHESIS-STUTTGART, P395

[3] 2-Sulfonyl-4-chloroanilino moiety: A potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfones [J].

Artico, M ;

Silvestri, R ;

Massa, S ;

Loi, AG ;

Corrias, S ;

Piras, G ;

LaColla, P .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (02) :522-530

[4] RAPID COLORIMETRIC ASSAY FOR CELL-GROWTH AND SURVIVAL - MODIFICATIONS TO THE TETRAZOLIUM DYE PROCEDURE GIVING IMPROVED SENSITIVITY AND RELIABILITY [J].

DENIZOT, F ;

LANG, R .

JOURNAL OF IMMUNOLOGICAL METHODS, 1986, 89 (02) :271-277

[5] BENZIMIDAZOLE RIBONUCLEOSIDES - DESIGN, SYNTHESIS, AND ANTIVIRAL ACTIVITY OF CERTAIN 2-(ALKYLTHIO) AND 2-(BENZYLTHIO)-5,6-DICHLORO-1-(BETA-D-RIBOFURANOSYL)BENZIMIDAZOLES [J].

DEVIVAR, RV ;

KAWASHIMA, E ;

REVANKAR, GR ;

BREITENBACH, JM ;

KRESKE, ED ;

DRACH, JC ;

TOWNSEND, LB .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (18) :2942-2949

[6]

Garuti L, 1998, ANTI-CANCER DRUG DES, V13, P397

[7] REACTION OF 2-(ALKYLSULFINYL)-BENZIMIDAZOLE, 2-(ARYLSULFINYL)-BENZIMIDAZOLE, AND 2-(ARALKYLSULFINYL)BENZIMIDAZOLE WITH THIOLS - A CONVENIENT SYNTHESIS OF UNSYMMETRICAL DISULFIDES [J].

GRABER, DR ;

MORGE, RA ;

SIH, JC .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (20) :4620-4622

[8] THE ANTIVIRAL COMPOUND ENVIROXIME TARGETS THE 3A CODING REGION OF RHINOVIRUS AND POLIOVIRUS [J].

HEINZ, BA ;

VANCE, LM .

JOURNAL OF VIROLOGY, 1995, 69 (07) :4189-4197

[9] COMPARISON OF THE ANTIVIRAL EFFECTS OF SUBSTITUTED BENZIMIDAZOLES AND GUANIDINE INVITRO AND INVIVO [J].

HERRMANN, EC ;

HERRMANN, JA ;

DELONG, DC .

ANTIVIRAL RESEARCH, 1981, 1 (05) :301-314

[10]

JAMOULLE JC, 1979, ANN PHARM FR, V37, P331

← 1 2 3 →