The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34

被引：80

作者：

Brown, SM ^{[1
]}

MacLean, AR ^{[1
]}

McKie, EA ^{[1
]}

Harland, J ^{[1
]}

机构：

[1] INST VIROL,GLASGOW G11 5JR,LANARK,SCOTLAND

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 12期

关键词：

D O I：

10.1128/JVI.71.12.9442-9449.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The herpes simplex virus (HSV) virulence factor ICP34.5, the mouse myeloid differentiation protein MyD116, and the hamster growth arrest and DNA damage protein GADD34 share a 63-amino-acid carboxyl domain which has significant homologies to otherwise divergent proteins, Here we report that both ICP34.5 and its cellular homolog MyD116 complex through the conserved domain with proliferating cell nuclear antigen, In addition, HSV infection induces a novel 70-kDa cellular protein detectable by antisera to both ICP34.5 and GADD34, demonstrating that this novel protein possesses homology with the 63-amino-acid conserved domain.

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页码：9442 / 9449

页数：8

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