Survivin, the starlet of the passenger protein complex. Check-up for its tenth anniversary

被引：3

作者：

Delacour-Larose, Marlene ^{[1
]}

Hoang, Thi My Nhung ^{[1
]}

Molla, Annie ^{[1
]}

机构：

[1] Univ Grenoble 1, Inst Albert Bonniot, INSERM, U823, F-38706 La Tronche, France

来源：

M S-MEDECINE SCIENCES | 2008年 / 24卷 / 10期

关键词：

D O I：

10.1051/medsci/20082410828

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Ten year after its discovery Survivin has gained Q strategic place within the chromosomal passenger complex. Whereas INCENP, Borealin and Aurora B are fully immobile in the complex, Survivin is mobile on centromere. Its mobility is regulated both by phosphorylation and ubiquitination. Survivin is a dynamic messenger that senses the central spindle tension and participates to the control of the mitotic chekpoint. In this review, we have detailed the multiple mitotic activities of Survivin and discussed them in light of the recent reported cristallographic data.

引用

页码：828 / 832

页数：5

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