The role of Kupffer cell oxidant production in early ethanol-induced liver disease

被引:205
作者
Wheeler, MD
Kono, H
Yin, M
Nakagami, M
Uesugi, T
Arteel, GE
Gäbele, E
Rusyn, I
Yamashina, S
Froh, M
Adachi, Y
Iimuro, Y
Bradford, BU
Smutney, OM
Connor, HD
Mason, RP
Goyert, SM
Peters, JM
Gonzalez, FJ
Samulski, RJ
Thurman, RG
机构
[1] Univ N Carolina, Dept Pharmacol, Hepatobiol & Toxicol Lab, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Pharmacol, Gene Therapy Ctr, Chapel Hill, NC 27599 USA
[3] NIEHS, Res Triangle Pk, NC 27709 USA
[4] New York Med Coll, New York, NY USA
[5] NCI, Bethesda, MD 20892 USA
关键词
adenovirus; superoxide dismutase; TNF alpha; NADPH oxidase; knockout mice; free radicals;
D O I
10.1016/S0891-5849(01)00748-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Considerable evidence for a role of Kupffer cells in alcoholic liver disease has accumulated and they have recently been shown to be a predominant source of free radicals. Several approaches including pharmacological agents, knockout trice. and viral gene transfer have been used to fill critical gaps in understanding key mechanisms by which Kupffer cell activation, oxidant formation and cytokine production lead to liver damage and subsequent pathogenesis. This review highlights new data in support of the hypothesis that Kupffer cell, play a pivotal role in hepatotoxicity due to ethanol by producing oxidants via NADPH oxidise. (C) 2001 Elsevier Science Inc.
引用
收藏
页码:1544 / 1549
页数:6
相关论文
共 43 条
[1]  
ADACHI Y, 1994, HEPATOLOGY, V20, P453, DOI 10.1002/hep.1840200227
[2]   ANTIBIOTICS PREVENT LIVER-INJURY IN RATS FOLLOWING LONG-TERM EXPOSURE TO ETHANOL [J].
ADACHI, Y ;
MOORE, LE ;
BRADFORD, BU ;
GAO, WS ;
THURMAN, RG .
GASTROENTEROLOGY, 1995, 108 (01) :218-224
[3]   The NF-kappa B and I kappa B proteins: New discoveries and insights [J].
Baldwin, AS .
ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :649-683
[4]  
BRADFORD BU, 1993, RES COMMUN SUBSTANCE, V14, P1
[5]   COMPARATIVE-STUDY OF CYTO-TOXICITY, TUMOR NECROSIS FACTOR, AND PROSTAGLANDIN RELEASE AFTER STIMULATION OF RAT KUPFFER CELLS, MURINE KUPFFER CELLS, AND MURINE INFLAMMATORY LIVER MACROPHAGES [J].
DECKER, T ;
LOHMANNMATTHES, ML ;
KARCK, U ;
PETERS, T ;
DECKER, K .
JOURNAL OF LEUKOCYTE BIOLOGY, 1989, 45 (02) :139-146
[6]   INCREASED OXYGEN RADICAL-DEPENDENT INACTIVATION OF METABOLIC ENZYMES BY LIVER-MICROSOMES AFTER CHRONIC ETHANOL-CONSUMPTION [J].
DICKER, E ;
CEDERBAUM, AI .
FASEB JOURNAL, 1988, 2 (13) :2901-2906
[7]  
DILUZIO NR, 1966, GASTROENTEROLOGY, V50, P392
[8]  
DING AH, 2000, J EXP MED, V167, P1154
[9]   EFFECT OF CHRONIC ETHANOL FEEDING ON RAT HEPATOCYTIC GLUTATHIONE - COMPARTMENTATION, EFFLUX, AND RESPONSE TO INCUBATION WITH ETHANOL [J].
FERNANDEZCHECA, JC ;
OOKHTENS, M ;
KAPLOWITZ, N .
JOURNAL OF CLINICAL INVESTIGATION, 1987, 80 (01) :57-62
[10]   GSH transport in mitochondria: Defense against TNF-induced oxidative stress and alcohol-induced defect [J].
FernandezCheca, JC ;
Kaplowitz, N ;
GarciaRuiz, C ;
Colell, A ;
Miranda, M ;
Mari, M ;
Ardite, E ;
Morales, A .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1997, 273 (01) :G7-G17