Biology of TGF-beta in knockout and transgenic mouse models

被引：145

作者：

Bottinger, EP ^{[1
]}

Letterio, JJ ^{[1
]}

Roberts, AB ^{[1
]}

机构：

[1] NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892

来源：

KIDNEY INTERNATIONAL | 1997年 / 51卷 / 05期

关键词：

D O I：

10.1038/ki.1997.185

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

This paper reviews the basic biology and biochemistry of the TGF-P isoforms including their unique serine-threonine receptors and signaling intermediates. Dysregulation of TGF-beta expression and/or recepotr/signaling function have been implicated in a wide variety of pathologies. We will discuss mechanisms underlying some of these disease processes as gained from study of transgenic mice in which expression of TGF-beta 1 has either been lost by targeted deletion of its gene, is overexpressed in a tissue-specific manner, or blocked by its latency associated peptide.

引用

页码：1355 / 1360

页数：6

共 69 条

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