Bayesian statistics in genetics - a guide for the uninitiated

被引:103
作者
Shoemaker, JS
Painter, IS
Weir, BS
机构
[1] Duke Univ, Med Ctr, Control Res Program, Durham, NC 27710 USA
[2] Talaria Inc, Seattle, WA 98104 USA
[3] N Carolina State Univ, Dept Stat, Raleigh, NC 27695 USA
关键词
D O I
10.1016/S0168-9525(99)01751-5
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Statistical analyses are used in many fields of genetic research. Most geneticists are taught classical statistics, which includes hypothesis testing, estimation and the construction of confidence intervals; this framework has proved more than satisfactory in many ways. What does a Bayesian framework have to offer geneticists? Its utility lies in offering a more direct approach to some questions and the incorporation of prior information. It can also provide a more straightforward interpretation of results. The utility of a Bayesian perspective, especially for complex problems, is becoming increasingly clear to the statistics community; geneticists are also finding this framework useful and are increasingly utilizing the power of this approach.
引用
收藏
页码:354 / 358
页数:5
相关论文
共 55 条
[1]   A Bayesian approach to the inference of diploid genotypes using haploid genotypes [J].
Alexander, HM ;
Slade, NA ;
Gomulkiewicz, R .
THEORETICAL AND APPLIED GENETICS, 1995, 91 (08) :1284-1287
[2]   THE POSTERIOR PROBABILITY-DISTRIBUTION OF ALIGNMENTS AND ITS APPLICATION TO PARAMETER-ESTIMATION OF EVOLUTIONARY TREES AND TO OPTIMIZATION OF MULTIPLE ALIGNMENTS [J].
ALLISON, L ;
WALLACE, CS .
JOURNAL OF MOLECULAR EVOLUTION, 1994, 39 (04) :418-430
[3]   Measuring departures from Hardy-Weinberg: a Markov chain Monte Carlo method for estimating the inbreeding coefficient [J].
Ayres, KL ;
Balding, DJ .
HEREDITY, 1998, 80 (6) :769-777
[4]  
Berger JO., 1985, Statistical Decision Theory and Bayesian Analysis, V2, DOI DOI 10.1007/978-1-4757-4286-2
[5]  
Berry DA, 1996, STAT BAYESIAN PERSPE
[6]  
BLANK RD, 1988, GENETICS, V120, P1073
[7]   POOLED-SAMPLING MAKES HIGH-RESOLUTION MAPPING PRACTICAL WITH DNA MARKERS [J].
CHURCHILL, GA ;
GIOVANNONI, JJ ;
TANKSLEY, SD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) :16-20
[8]  
COHEN J, 1994, AM PSYCHOL, V49, P997, DOI 10.1037/0003-066X.50.12.1103
[9]  
Durbin R., 1998, BIOL SEQUENCE ANAL
[10]   PRIOR PROBABILITY OF AUTOSOMAL LINKAGE [J].
ELSTON, RC ;
LANGE, K .
ANNALS OF HUMAN GENETICS, 1975, 38 (JAN) :341-350