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The expression of proinflammatory cytokine mRNA in the sciatic-tibial nerve of ischemia-reperfusion injury

被引：28
作者：
Mitsui, Y
Okamoto, K
Martin, DP
Schmelzer, JD
Low, PA
机构：
[1] Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Dept Anesthesiol, Rochester, MN 55905 USA
来源：
BRAIN RESEARCH | 1999年 / 844卷 / 1-2期
关键词：
TNF-alpha; IL-1; beta; ischemia; reperfusion; nerve; cytokines;
D O I：
10.1016/S0006-8993(99)01830-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We evaluated the proinflammatory cytokines, TNF-alpha and IL-1 beta, mRNA expression in the rat sciatic and tibial nerves following ischemia-reperfusion (IR) injury, using competitive RT-PCR, to explore the role of cytokines in IR injury. The expressions of both TNF-alpha and IL-1 beta mRNA were related to severity of ischemia and occurred with reperfusion rather than ischemia alone. TNF-alpha gene expression peaked at 24 h of reperfusion, while that of IL-1 beta peaked at 12 h. These data support the notion that the proinflammatory cytokines TNF-alpha and IL-1 beta are involved in the inflammatory response of IR injury to the peripheral nervous system and may be involved in the pathophysiology of ischemic fiber degeneration. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：192 / 195
页数：4
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